
THERAPY-Magazin
The MoS
The TheMoS project is developing an S3 guideline to standardise therapy for mobility disorders after stroke. Learn how this evidence-based approach aims to improve care and patient outcomes.

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THERAPY Magazin
TheMoS project partners want to develop an S3 guideline for the treatment of mobility disorders after a stroke, and thereby promote the standardisation of treatment in neurorehabilitation. The therapy recommendations should follow specific target criteria, such as the ability to learn to walk independently or a reduction in falls.
In Germany alone, around 1.6% of adults suffer a stroke every year, which can lead to significant mobility impairments. In a pioneering project called TheMoS, a medical S3 guideline is currently being developed to improve the treatment of mobility disorders after a stroke.
The TheMoS project aims to develop an S3 guideline for the treatment of mobility disorders following a stroke.
Background: Stroke and mobility impairments
Strokes have a considerable impact on the mobility of those affected. Around two-thirds of patients are in need of care or assistance in everyday life after a stroke. This makes stroke the most common cause of acquired disability in adulthood. The resulting mobility impairments are often decisive for the need for care levels or even full residential accommodation.
The importance of prompt and consistent therapy in overcoming these limitations should not be underestimated. Effective interventions can significantly reduce the impact of the disorders and enable patients to regain their independence.
Strokes have a considerable impact on the mobility of those affected. Around two-thirds of patients are in need of care or assistance in everyday life after a stroke. This makes stroke the most common cause of acquired disability in adulthood. The resulting mobility impairments are often decisive for the need for care levels or even full residential accommodation.
The importance of prompt and consistent therapy in overcoming these limitations should not be underestimated. Effective interventions can significantly reduce the impact of the disorders and enable patients to regain their independence.
An S3 guideline is a medical guideline categorised as having the highest level of evidence in the German healthcare system.
The TheMoS project: Goals and approach
The TheMoS project aims to develop an S3 guideline for the treatment of mobility disorders following a stroke. The focus is on improving the standardisation of therapeutic approaches. The new guideline will replace the existing S2k guideline “Rehabilitation of mobility after stroke” (ReMoS).
A key aspect of the project is the systematic development of target group-specific versions of the guideline. This is made possible by the involvement of various professional groups and disciplines such as neurology, general medicine and geriatric medicine. The perspective of those affected is also taken into account by actively involving patient representatives.
The TheMoS project aims to develop an S3 guideline for the treatment of mobility disorders following a stroke. The focus is on improving the standardisation of therapeutic approaches. The new guideline will replace the existing S2k guideline “Rehabilitation of mobility after stroke” (ReMoS).
A key aspect of the project is the systematic development of target group-specific versions of the guideline. This is made possible by the involvement of various professional groups and disciplines such as neurology, general medicine and geriatric medicine. The perspective of those affected is also taken into account by actively involving patient representatives.
Funding and duration of the project
TheMoS is being funded for two and a half years with around €449,000. This will enable the project partners to carry out comprehensive research and development in order to produce an evidence-based and practice-orientated guideline..
TheMoS is being funded for two and a half years with around €449,000. This will enable the project partners to carry out comprehensive research and development in order to produce an evidence-based and practice-orientated guideline..
Research logic and recommendation development
TheMoS’s research logic is based on established recommendations for the development of guidelines by the German Association of Scientific Medical Societies (AWMF). This includes joint recommendations from the Cochrane Germany Foundation, the Institute for Evidence in Medicine, the Institute for Medical Biometry and Statistics in Freiburg, the AWMF Institute for Medical Knowledge Management, and the Medical Centre for Quality in Medicine (ÄZQ) on systematic research for evidence syntheses and guidelines. Furthermore, the recommendations on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) are taken into account.
Once the recommendations have been agreed, target group-specific dissemination and implementation aids for various professional groups will be developed based on the results of a literature review and topic-based interviews.
TheMoS’s research logic is based on established recommendations for the development of guidelines by the German Association of Scientific Medical Societies (AWMF). This includes joint recommendations from the Cochrane Germany Foundation, the Institute for Evidence in Medicine, the Institute for Medical Biometry and Statistics in Freiburg, the AWMF Institute for Medical Knowledge Management, and the Medical Centre for Quality in Medicine (ÄZQ) on systematic research for evidence syntheses and guidelines. Furthermore, the recommendations on the Grading of Recommendations Assessment, Development and Evaluation (GRADE) are taken into account.
Once the recommendations have been agreed, target group-specific dissemination and implementation aids for various professional groups will be developed based on the results of a literature review and topic-based interviews.
Outlook and potential
If successful, the new S3 guideline will not only contribute to better care for patients with mobility disorders after a stroke, but will also focus on continuous quality control of the recommended therapies. This could make a significant contribution to improving the quality of life of stroke survivors and minimising the long-term complications of the disease. TheMoS thus demonstrates how innovative approaches in guideline development can help to optimise patient care and create a broad basis for the treatment of mobility disorders after a stroke.
If successful, the new S3 guideline will not only contribute to better care for patients with mobility disorders after a stroke, but will also focus on continuous quality control of the recommended therapies. This could make a significant contribution to improving the quality of life of stroke survivors and minimising the long-term complications of the disease. TheMoS thus demonstrates how innovative approaches in guideline development can help to optimise patient care and create a broad basis for the treatment of mobility disorders after a stroke.

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References:
- https://innovationsfonds.g-ba.de/projekte/versorgungsfor- schung/themos-entwicklung-der-medizinischen-s3-leitlinie- zur-therapie-der-mobilitaet-nach-schlaganfall.580
- https://www.eah-jena.de/forschung/projekt/themos
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